BCMB Students: 2014 Entering Class

Thesis Lab:

John Petrini

Undergraduate University: University of Florida

Thesis Lab:

Charles Sawyer

Undergraduate University: Jilin University

Publications:

• Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation
• Organoid cultures derived from patients with advanced prostate cancer
• PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
• Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth
• Alternative transcription initiation leads to expression of a novel ALK isoform in cancer
• Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC
• SOX2 promotes lineage plasticity and antiandrogen resistance in TP53-and RB1-deficient prostate cancer
• ETV1-positive cells give rise to BRAF^V600E-mutant gastrointestinal stromal tumors
• The cell cycle restricts activation-induced cytidine deaminase activity to early G1
• Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
• FOXF1 defines the core-regulatory circuitry in gastrointestinal stromal tumor (GIST)
• COP1-DET1-ETS axis regulates ERK transcriptional output and modulates sensitivity in MAPK inhibitors

Thesis Lab:

Michael Overholtzer

Undergraduate University: St. John's University

Thesis Lab:

Danwei Huangfu

Undergraduate University: University of California, Berkeley

Thesis Lab:

Alessio Accardi

Undergraduate University: Drew University

Thesis Lab:

Timothy Chan

Undergraduate University: Princeton University

Publication:

• Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells

Thesis Lab:

Lukas Dow

Undergraduate University:  Beijing University of Technology

Publication:

• Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
• R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Thesis Lab:

Luis Parada

Undergraduate University: University of Southern California

Thesis Lab:

Samie Jaffrey

Undergraduate University: Cornell University

Publication:

• In-gel imaging of RNA processing using broccoli reveals optimal aptamer expression strategies

Thesis Lab:

Greg Petsko

Undergraduate University: University of New Haven 

Thesis Lab:

Todd Evans

Undergraduate University: Cornell University

Thesis Lab:

Michael Overholtzer

Undergraduate University: Washington University in St. Louis

Thesis Lab:

Scott Lowe

Undergraduate University: China Agricultural University

Thesis Lab:

Renier Brentjens

Undergraduate University: Peking University

Thesis Lab:

Lewis Cantley

Undergraduate University: National Taiwan University

Thesis Lab:

John Blenis

Undergraduate Univesity: New York University CAS

Thesis Lab:

Lewis Cantley

Undergraduate University: University of California, Irvine

Thesis Lab:

Michel Sadelain

Undergraduate University: Bombay College of Pharmacy

Publication:

• Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Thesis Lab:

John Blenis

Undergraduate University: UC Berkeley

Publication:

• Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Thesis Lab:

Sarat Chandarlapaty

Undergraduate University: Colby College