News | Graduate School of Medical Sciences

illustration of TMEM16F protein in closed and open conformations

Weill Cornell Medicine investigators have revealed the detailed workings of a cell membrane protein that has essential roles in all animals. The discovery could lead to new therapeutic strategies for blood coagulation disorders, cancers and other conditions in which the protein, called a TMEM16 scramblase, works abnormally.

Scramblases operate within cell membranes, where they alter or “scramble” the normal layered arrangement of lipid...

Disrupting Genome Architecture Selectively Impairs Developmental Genes

Temporarily disabling a protein complex that organizes DNA into loops inside the cell’s nucleus drastically disrupted the three-dimensional structure of the genome, but surprisingly most genes continued to function as usual, Weill Cornell Medicine researchers found. However, they also discovered a small group of affected genes that play a critical role in guiding cells to become specific types, for example heart, brain, or liver cells.

The study, published April 13 in Nature Genetics,...

Reimagining Medicaid to Safeguard America’s Children

As states reassess Medicaid coverage following recent federal policy changes and the end of pandemic-era protections, researchers are advocating for evidence-based health care policy reform and expanded Medicaid coverage for children. Weill Cornell Medicine’s Department of Pediatrics, the Cornell Health Policy Center (CHPC) and Ariadne Labs are collaborating to launch the Era of the Child Initiative, which supports the design and implementation of effective policies to improve U.S. children’...

illustration of cancer cells surrounding and within bladder

American Cancer Society Grant to Fund Research on Urinary Tract Cancer Therapies

A $1 million Research Scholar Grant from the American Cancer Society will help a multi-institution team led by Dr. Bishoy Faltas, associate professor of medicine at Weill Cornell Medicine, to develop new therapy combinations for hard-to-treat urinary tract cancers.

New therapies combining enfortumab vedotin and pembrolizumab dramatically improved outcomes for patients with advanced cancers of the cells lining the urinary tract and bladder. Yet about one-third of patients do not respond...

Research Shifts Toward Shared Mechanisms in Neurodegenerative Diseases

Alzheimer’s disease may not be a single illness, but a complex web of overlapping brain disorders that scientists have just started to untangle. Leaders in the field discussed this shift in research at the recent 13th annual Helen and Robert Appel Alzheimer’s Disease Research Institute Symposium held in the Belfer Research Building at Weill Cornell Medicine.

“The vision of the Appel Institute is simple. We wanted to tackle some of the most devastating...

Burnout May Lead Family Doctors to Leave Medicine

Family physicians who report feeling burned out are nearly 1.5 times more likely to change practices or stop practicing medicine entirely compared to their peers who don’t report burnout, a study by Weill Cornell Medicine researchers found. Physician burnout can include emotional exhaustion, detachment from patients and colleagues, and feeling that work is no longer meaningful.

The findings, published March 30 in JAMA Internal Medicine, also highlight the consequences for patients:...

clasped hands of man facing torso of seated doctor with clipboard

Prostate Cancer Foundation Awards Grants to Weill Cornell Medicine Investigators

Six researchers from Weill Cornell Medicine have received Young Investigator Awards from the Prostate Cancer Foundation. These three-year grants award $225,000 to postdoctoral fellows and early-career faculty, helping to energize the field with fresh ideas. The Weill Cornell investigators are part of thirty-one researchers overall who were selected for the PCF’s Class of 2025 Young Investigators. The awardees will investigate how the disease occurs at a molecular level, search for new...

AI Tool Shows Promise in Diagnosing Advanced Heart Failure

Applying artificial intelligence techniques to cardiac ultrasound data may make it easier to identify patients with advanced heart failure, a new study has found. The study—led by investigators at Weill Cornell Medicine, Cornell Tech, Cornell Ann S. Bowers College of Computing and Information Science, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian—offers the prospect of better care for many thousands of patients who may be overlooked due to the...

little boy in bed with parents hand on head checking for fever

How One Flu Virus Can Hamper the Immune Response to Another

Prior exposure to one strain of influenza virus may weaken children’s ability to mount an effective antibody response against their subsequent exposure to a different flu strain, according to a study led by Weill Cornell Medicine investigators. The analysis of the pediatric response to H3N2 and H1N1 influenza A viruses, two of the most common causes of flu, provides insight into the concept of “immune imprinting,” and supports the idea that childhood vaccination, if...

Study Identifies Gene Linked to Chemotherapy Resistance in Prostate Cancer

A gene called FOXJ1 may drive resistance to taxane chemotherapy during treatment for advanced prostate cancer, according to a new study led by investigators at Weill Cornell Medicine and Beth Israel Deaconess Medical Center. The findings provide important new insights into why patients with metastatic disease often stop responding to a key class of life-prolonging chemotherapy drugs after initially benefiting. Given that taxanes remain the only chemotherapy agents with demonstrated survival...

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