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A protein induced by gut microbes is vital in healing colons that have become inflamed due to a short-term form of colitis, Weill Cornell Medicine researchers discovered in a new study. However, they also found that this molecule, called TNF-like ligand 1A (TL1A) contributes to the sustained inflammation characterized by chronic inflammatory bowel disease (IBD).

In a study published Dec. 11 in Immunity,...

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By Beth Saulnier
Photos by Stephanie Diani

When Dr. Sandeep “Sunny” Kishore, PhD ’12, MD ’14, gave the commencement speech for the Class of 2014, he stood onstage in Carnegie Hall and confessed something: as a third-year medical student, he’d initially failed his surgical “shelf” exam, one of the rigorous tests given after each core rotation. Having resumed his MD studies after a lauded five years as a doctoral...

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Common drug treatments that lead to changes in gut fungi can persistently exacerbate allergic airway diseases such as asthma, according to a study by Weill Cornell Medicine researchers.

The study, published online Nov. 29 in Cell Host & Microbe, suggests that the enormous modern prevalence of allergic airway diseases may be attributable in part to the widespread use of antimicrobials, including...

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A study of the dual pathways that process the essential vitamin folate by Weill Cornell Medicine investigators unexpectedly revealed a new way the cancer drug methotrexate works and may suggest strategies to boost its cancer-killing effects.

For the study, published Nov. 29 in Cell, the investigators used genome editing and biochemical experiments to show that interfering with folate metabolism in the cell’s energy-...

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Weill Cornell Medicine has been awarded a five-year, $9 million Program Project Grant (P01) from the National Cancer Institute (NCI) to better understand how and why patients with an aggressive and incurable form of lymphoma initially respond to treatment, only to relapse over time. The findings may enable investigators to develop superior therapies that are effective, well tolerated and tailored to individual patients with mantle cell lymphoma.

The NCI, part of the National...

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Measuring brain activity in response to hearing a brief narrative can identify patients with severe brain injury who have preserved high-level cognition despite showing limited or no consciousness at the bedside, according to a study by Weill Cornell Medicine researchers.

The paper, published Nov. 21 in Current Biology, is the first to describe a method for measuring the delay in brain processing of...

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Scientists can now discover how the fine details of gene activity differ from one cell type to another in a tissue sample, thanks to a technique invented by Weill Cornell Medicine researchers.

The technique, described in a paper published Oct. 15 in Nature Biotechnology, will enable biologists to better understand the distinct molecular workings of different cell types in the body. It may also enable the improved understanding and...

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Consuming a high-fat, high-sugar diet causes a harmful accumulation of fat in the liver that may not reverse even after switching to a healthier diet, according to a new study by scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center.

For the study, published Oct. 3 in Science Translational Medicine, the investigators developed a nanosensor that can detect and noninvasively track the accumulation...

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Eight Weill Cornell Medicine faculty members have been selected for the fifth round of the Daedalus Fund for Innovation awards, a pioneering institutional program that helps advance promising applied and translational research projects and emerging technologies that have commercial potential. Awardees are chosen twice annually and...

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Weill Cornell Medicine
Graduate School of Medical Sciences
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