News | Graduate School of Medical Sciences

Study Identifies Gene Linked to Chemotherapy Resistance in Prostate Cancer

A gene called FOXJ1 may drive resistance to taxane chemotherapy during treatment for advanced prostate cancer, according to a new study led by investigators at Weill Cornell Medicine and Beth Israel Deaconess Medical Center. The findings provide important new insights into why patients with metastatic disease often stop responding to a key class of life-prolonging chemotherapy drugs after initially benefiting. Given that taxanes remain the only chemotherapy agents with demonstrated survival...

Prior Authorization Bans for Buprenorphine Alone May Not Improve Treatment Retention

State laws that ban insurance prior authorization for buprenorphine—a leading medication for opioid use disorder—may not help more patients stay in treatment for the recommended minimum of 180 days, Weill Cornell Medicine researchers report. Though prescription buprenorphine can be a life-saving treatment that relieves opioid cravings and withdrawal symptoms, adherence to the medication is low.

Published March 6 in JAMA Health Forum, the study examined whether state laws prohibiting...

pregnant woman having blood pressure taken

New Model May Predict Preeclampsia in Late Pregnancy

A machine-learning model developed by Weill Cornell Medicine investigators may provide clinicians with an early warning of a complication that can occur late in pregnancy.

Weill Cornell Medicine Selected for Prostate Cancer Foundation Challenge Award

Dr. Ekta Khurana, an associate professor of systems and computational biomedicine at Weill Cornell Medicine, has received a two-year, $1 million Challenge Award from the Prostate Cancer Foundation to work with researchers from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center on an AI-based method for early detection of treatment-resistant prostate tumor subtypes.

Dr. Ekta Khurana

New Strategies Aim at HIV’s Last Strongholds

A new study has overcome a long-standing challenge—how to isolate and study elusive HIV-infected cells called authentic reservoir clones (ARCs) that evade the immune system, making the disease difficult to cure. Researchers from Weill Cornell Medicine, Rockefeller University, and collaborating institutions offer a unprecedented look into these hidden HIV‑harboring cells and show that some may be more vulnerable to immune destruction than previously believed.

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Triggering Self-Combustion in Fat Cells for Weight Loss

Ordinary fat cells in obese animals can be induced to burn energy stores, generating substantial heat, according to a preclinical study by Weill Cornell Medicine investigators.

In the study, published Feb. 23 in Nature Metabolism, the researchers showed that in fat cells called white adipocytes, high levels of fatty acids from fat stores, in the presence of a key enzyme called AAC, can trigger a process that uses fat to produce heat and increase energy expenditure. They demonstrated...

How Food Shortages Reprogram the Immune System’s Response to Infection

When food is scarce, stress hormones direct the immune system to operate in “low power” mode to preserve immune function while conserving energy, according to researchers at Weill Cornell Medicine. This reconfiguration is crucial to combating infections amid food insecurity.

“Both famine and infectious disease have been with us throughout our evolutionary history and often occurred at the same time. Yet little is known about how nutrition affects the immune system,” said senior author...

Extreme Risk Protection Order Laws Reduce Firearm Suicides

A new study found that laws temporarily restricting access to firearms for individuals at high risk of harming themselves or others reduced firearm suicides without a shift to other suicide methods, according to researchers at Weill Cornell Medicine and UC Berkeley School of Public Health.

Dr. Yunyu Xiao

In 2023, more than half of all suicide deaths in the United States involved firearms. To address this crisis, “red flag” laws—...

Gut Bacteria May Tip the Balance between Feeding Tumors and Fueling Immunity

A new study reveals how bacteria in the gut can help determine whether the amino acid asparagine from the diet will feed tumor growth or activate immune cells against the cancer, according to researchers at Weill Cornell Medicine. This casts the gut microbiome—the trillions of microorganisms living in the intestine—as a central player in the body's response to cancer and to modern cancer treatments like immunotherapies.

Dr. Chunjun (CJ) Guo...

Image of spatial transcriptome analysis in the gut

Discovery Illuminates How Inflammatory Bowel Disease Promotes Colorectal Cancer

A chain of immune reactions in the gut—driven by a key signaling protein and a surge of white blood cells from the bone marrow—may help explain why people with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer, according to a preclinical study by Weill Cornell Medicine investigators. The findings point to new possibilities for diagnosis, monitoring and treatment of IBD.

The study began with a focus on TL1A, an inflammatory immune signaling protein known to be...

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