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Composite of a cryo-electron microscopy image showing lipid vesicles with embedded Piezo channels, and the Piezo channel structure (top). Topography image of a single Piezo channel under force as recorded by high-speed atomic force microscopy (circle) and its lateral expansion in the membrane as a function of applied force (right). All images:Dr. Simon Scheuring.)

Scientists Discover the Basics of how Pressure-sensing Piezo Proteins Work

A team of scientists from Weill Cornell Medicine and The Rockefeller University has illuminated the basic mechanism of Piezo proteins, which function as sensors in the body for mechanical stimuli such as touch, bladder fullness and blood pressure. The discovery is a feat of basic science that also opens up many new paths of investigation into the roles of Piezo proteins in human diseases and potential new therapeutic strategies.

In the study, published Aug. 21 in Nature, the scientists...

Four Weill Cornell Medicine women physicians and scientists

Four Faculty Members Named Crain’s Notable Women in Healthcare

Four distinguished Weill Cornell Medicine physician-scientists – Drs. Silvia Formenti, Barbara Hempstead, Lisa Newman and Laura Riley – have been selected as Crain’s Notable Women in Healthcare in New York City.

The Weill Cornell Medicine awardees are part of a list of 100 women chosen by Crain’s New York Business for outstanding professional and philanthropic achievements in New York City, as well as proven commitments to mentorship and the promotion of diversity and inclusion in the...

From left: Drs. Laura Riley, Barbara Hempsetad, Silvia Formenti and Lisa Newman named in Crain's 2019 Notable Women in Healthcare. Credit: Roger Tully

Four Faculty Members Named Crain’s Notable Women in Health Care

Visualizing innate lymphoid cells in the mouse lymph node: ILCs (green), B cells (cyan), T cells (magenta). Image courtesy of Dr. Saya Moriyama and Dr. David Artis

Discovery May Open Up New Possibilities for Treating Allergic Inflammatory Diseases

A molecule best known for its association with migraines may be a key to new treatments for common worm infections as well as allergic inflammatory disorders such as asthma, according to a study from scientists at Weill Cornell Medicine and the National Institutes of Health (NIH).

The scientists, whose work was published July 25 in Immunity, found a subset of white blood cells that reside in the lungs of mammals and produce the molecule, called CGRP, during worm infection in mice. The...

‘A Beacon of Hope’

By Amy Crawford

Dr. Juan Cubillos-Ruiz got his first look at ovarian cancer early in his doctoral research, which focused on understanding how the microenvironment of a tumor affects a patient’s immune system. “It was one of my first experiments,” recalls Dr. Cubillos-Ruiz, now an assistant professor of microbiology and immunology in obstetrics and gynecology at Weill Cornell Medicine, where he is also a member of the Sandra and Edward Meyer Cancer Center. “I got a specimen from a patient to...

Stressful Situation: A scientific illustration shows how T-cells that are exposed to harsh conditions inside a tumor experience endoplasmic reticulum (ER) stress, depicted by “burning” ER (orange) surrounding the nucleus (purple and turquoise). Mitochondria are seen in bluish gray, with cancer cells in red. Credit: Ella Maru Studio

A Beacon of Hope: Dr. Juan Cubillos-Ruiz Aims to Improve Survival Rates for Ovarian Cancer

By Amy Crawford

Weill Cornell Medicine Physician Assistant Named PA of the Year

Matthew Laghezza, chief physician assistant in the Department of Emergency Medicine at Weill Cornell Medicine and the Lisa Perry Emergency Center at NewYork-Presbyterian/Weill Cornell Medical Center, was named 2018 Emergency Medicine Physician Assistant of the Year by the Society of Emergency Medicine Physician Assistants.

The award recognizes physician assistants who demonstrate exceptional service and leadership in emergency medicine, the emergency medicine physician assistant...

IMSD Students Rafael Colon, Viktor Belay, Amanda Simon and Valerie Gallegos

Weill Cornell Graduate School Receives Prestigious Grant to Boost Underrepresented Groups

The Weill Cornell Graduate School of Medical Sciences has been awarded a competitive grant from the National Institutes of Health to launch a program dedicated to increasing the number and enhancing the success of doctoral students from underrepresented backgrounds.

The five-year, $2.4 million award from the National Institute of General Medical Sciences of the National Institutes of Health will fund the Weill Cornell Initiative to Maximize Student Development...

Innovative Single-Cell Genomics Technology Allows Study of Cancer Evolution in Unprecedented Detail

A new technology devised by scientists at Weill Cornell Medicine and the New York Genome Center (NYGC) enables the measurement of gene mutations and their effects on gene activity within individual cancer cells biopsied from patients.

The advance, reported July 3 in Nature, allows researchers to study, in unprecedented detail, the complex dynamics of cancerous cell populations during the course of disease and in response to therapies. That could lead to more effective new anticancer...

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