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Study Illuminates Role of Gut Microbes in the Response to TB Treatment

Gut bacteria play an important role in the body’s response to treatment for tuberculosis (TB), according to researchers at Weill Cornell Medicine and Memorial Sloan Kettering. Because current treatments for TB involve long courses of antibiotics, which are known to disrupt the balance of microbes in the gut, a better understanding of these interactions may help in predicting outcomes to therapy and suggest ways to improve it.

In their...

Study Brings Neuroscience a Step Closer to a High-Resolution Mammalian Brain Atlas

A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain.

Isoform variation is a process that extends the versatility of...

RNA splicing in cancer

April 21, 2021 - 12:00pm

Physiology, Biophysics and Systems Biology (PBSB) Seminar Series presents: Robert K. Bradley, Ph.D. Professor, Public Health Sciences and Basic Sciences Divisions McIlwain Family Endowed Chair in Data Science Fred Hutchinson Cancer Research Center Hosted by Eric Lai, Ph.D.

Diversity Week - Racial Battle Fatigue

April 26, 2021 - 11:00am

Emergency Medicine William A. Smith, PhD Professor & Department Chair Department of Education, Culture, & Society Professor of Ethnic Studies (African American Studies Division) University of Utah

Identifying reproducible cell type-specific molecular changes in neurodegenerative disease

April 26, 2021 - 12:00pm

Institute for Computational Biomedicine (ICB) Seminar Series presents: Vilas Menon, Ph.D. Assistant Professor Department of Neurology Columbia University Irving Medical Center Hosted by Drs. Doron Betel and Olivier Elemento For Zoom details, please contact Churece Thompson (cnf4001@med.cornell.edu).

Potentiating Innate Immunity with Engineered CAR T Cells

Date: Monday, April 19, 2021 - 3:00pm

MEGAN M. DACEK

Pharmacology

Chairperson: Dr. Derek Tan

Major Sponsor: Dr. David Scheinberg

Minor Sponsor: Dr. Richard O'Reilly

Minor Sponsor: Dr. Marcel van den Brink

The Molecular Resetting of Pluripotent Stem Cell Identity during Mitotic Exit

Date: Thursday, April 22, 2021 - 2:00pm

BOBBIE PELHAM-WEBB (MD-PhD)

Physiology, Biophysics and Systems Biology

Chairperson: Dr. Todd Evans

Major Sponsor: Dr. Effie Apostolou

Minor Sponsor: Dr. Danwei Huangfu

Minor Sponsor: Dr. Steven Josefowicz

Additional Member(s): Drs. Charles Danko (Cornell Univesity, Ithaca), Anna-Katerina Hadjantonakis (MSKCC)

Drivers of CD8 T cell Dysfunction in Tumors

Date: Monday, May 3, 2021 - 2:00pm

MOJDEH SHAKIBA

Physiology, Biophysics and Systems Biology

Chairperson: Dr. Doron Betel

Major Sponsor: Dr. Andrea Schietinger

Minor Sponsor: Dr. Ming Li

Minor Sponsor: Dr. Jedd Wolchok

Congratulations to Our NSF Fellows and Honorable Mention Applicants

The National Science Foundation Graduate Research Fellowship Program (NSF GRFP) ensures the quality, vitality, and diversity of the scientific research in the United States. This prestigious program recognizes and funds outstanding graduate students who are pursuing research-based master's and doctoral degrees in science, technology, engineering, and mathematics (STEM).

WCGS students experience high success rates each year, and here, we highlight the two awardees and six students who...

Student Spotlight: Ke Xu, Ph.D. '21

2021 marks the 100th anniversary of the discovery of aerobic glycolysis by German physician Otto Warburg—the Warburg Effect. Warburg discovered that fast-proliferating cancer cells produce energy from glucose in an inefficient manner. Rather than oxidizing the glucose molecule with oxygen inside of mitochondria, cancer cells catabolize it via lactate dehydrogenase (LDH)-mediated fermentation. This oxygen-independent process occurs quickly but leaves much of the energy in glucose untouched....

Tri-I CBM Student Develops a Method to Measure Differential Splicing Differences and Quantify the Differences in Transcript Usage

Anoushka Joglekar grew up in Pune, India, a metropolis with rich historical and cultural roots dating back several centuries. Joglekar came to the United States to pursue her undergraduate studies at the Ohio State University and joined the Tri-I Computational Biology and Medicine (Tri-I CBM) in 2017. Part of WCGS’s appeal was the direct access to some of the greatest research labs in the country. “I...

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