BCMB Allied Program Entering Class

Undergraduate University: Ursinus College 

Publications:

• Prion-dependent proteome remodeling in response to environmental stress is modulated by prion variant and genetic background

Undergraduate University: Washington University 

Undergraduate University: NYU 

Publications:

• De novo assembly and delivery to mouse cells of a 101 kb functional human gene

Undergraduate University: University of Pittsburgh 

Undergraduate University: University of Kentucky 

Publications:

• cAMP-mediated regulation of melanocyte genomic instability: a melanoma-preventive strategy. Advances in Protein Chemistry and Structural Biology
• Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor-intact or heterozygous skin.
• Divergence of cAMP signaling pathways mediating augmented nucleotide excision repair and pigment induction in melanocytes.

• Paracrine regulation of melanocyte genomic stability: a focus on nucleotide excision repair

 Undergraduate University: Tufts University 

Undergraduate University: Zhejiang University 

Undergraduate University: University of Illinois 

Undergraduate University: University of Texas 

Publications:

• Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

Undergraduate University: Georgetown University 

Undergraduate University: Duke University 

Undergraduate University: Georgia Tech 

Undergraduate University: Osnabrueck University

Publications:

• Membrane Solubilization by Styrene-Maleic Acid Copolymers: Delineating the Role of Polymer Length

• Ceramides bind VDAC2 to trigger mitochondrial apoptosis

• Factors influencing the solubilization of membrane proteins from Escherichia coli membranes by styrene-maleic acid copolymers

Undergraduate University: Columbia University 

Publications:

• Skeletal myogenesis in vitro: current triumphs and tribulations in deriving skeletal muscle from human pluripotent stem cells. Manuscript in Preparation
• QSER1 protects DNA methylation valleys from de novo methylation

• Real-Time PCR Detection of Burkholderia cepacia in Pharmaceutical Products Contaminated with Low Levels of Bacterial Contamination

• Direct PCR detection, cloning, and characterization of bacterial glucosidase genes from temperate soils.

Undergraduate University: UC Berkeley

 Publications:

• An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants

• KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice

Undergraduate University: Cornell University 

Undergraduate University: UNC-Chapel Hill 

Undergraduate University: Freie Universität Berlin 

Undergraduate University: Brandeis University 

Undergraduate University: University of Nottingham 

Undergraduate University: Northeastern University

Publications:

• Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
• Gating choreography and mechanism of the human proton-activated chloride channel ASOR.

Undergraduate University: New York University

Publications:

• CRISPR in cancer biology and therapy

• Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

• GO: a functional reporter system to identify and enrich base editing activity

• Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition

• Tankyrase inhibition sensitizes cells to CDK4 blockade
• Identification of cancer drivers at CTCF insulators in 1,962 whole genomes

• Pressure and Stretch Differentially Affect Proliferation of Renal Proximal Tubular Cells”

Undergraduate University: University of Newcastle

Undergraduate University: Northeastern University

Publications:

• A non-canonical tricarboxylic acid cycle underlies cellular identity.(accepted)

• Tumor-produced aging-associated oncometabolite, methylmalonic acid, promotes cancer-associated fibroblast activation to drive metastatic progression (under revision)
• Targeting oncoproteins with a positive selection assay for protein degraders.
• Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics
• Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia
• Age-induced accumulation of methylmalonic acid promotes tumor progression
• Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

• Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
• HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species

Undergraduate University: New York University

Publications:

• A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage

• Immune Cell-Stromal Circuitry in Lupus Photosensitivity

Undergraduate University: National Taiwan University

Publications:

• Immunity beyond cancer cells: perspective from tumor tissue

• Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis”

• Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis

Undergraduate University: Boston University

Publications:

• Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations

• Correlation of membrane protein conformational and functional dynamics

Undergraduate University: Northeastern University

Publications:

• Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Undergraduate Univeristy: Tsinghua University

Publications:

• Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma

Undergraduate University: New York University

Publications:

• Superresolution visualization of distinct stalled and broken replication fork structures.

• “Building the Base: Why a More Diverse, Communication-Savvy Scientific Workforce is the Key to Addressing Future Catastrophes,” Science & Diplomacy.(Science & Diplomacy magazine)

Undergraduate University: CUNY York College

Undergraduate University: UCLA

Publications:

• ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs

Undergraduate University: Imperial College, London

Publications:

• Understanding the source of METTL3-independent m6A in mRNA.(manuscript in progress)
• The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells
• Structure mapping of dengue and Zika viruses reveals functional long-range interactions

Undergraduate University: Tufts University

Publications:

• Sequence and nuclease requirements for breakage and healing of a Structure-Forming (AT)n sequence within fragile site FRA16D 

• Identification of epsilon toxin-producing Clostridium perfringens strains in American retail food 

• Enrichment and Detection of Clostridium perfringens Toxinotypes in Retail Food Samples 

Undergraduate University: University of Washington, Seattle

Publications:

• Choroid plexus orchestrates leptomeningeal immunity (in preparation)
• Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites (in submission)
• The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites

• Characterization, isolation, and in vitro culture of leptomeningeal fibroblasts

• Leptomeningeal metastatic cells adopt two phenotypic states

• Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases

• Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters. Nature Scientific Report
• Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
• Cool night-time temperatures induce the expression of CONSTANS and FLOWERING LOCUS T to regulate flowering in Arabidopsis

Undergraduate University: Binghamton University 

Undergraduate University: UCLA

Publications:

• Germline competency of human embryonic stem cells depends on eomesodermin

• The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation

• Tankyrase inhibition sensitizes cells to CDK4 blockade

• GO: a functional reporter system to identify and enrich base editing activity

  
  

Undergraduate University: Harvard University

Undergraduate University: UCLA

Undergraduate University: University of Pennsylvania

Undergraduate University: CUNY- Queens College

Publications:

• Mechanisms of differential desensitization of metabotropic glutamate receptors

• Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling

• Structural basis for KCTD-mediated rapid desensitization of GABA B signalling

• Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse

Undergraduate University: SUNY- GENESO

Publications:

• Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells

• APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

• The APOBEC3A deaminase drives episodic mutagenesis in cancer cells

Undergraduate University: Cornell University

Undergraduate University: Syracuse University

Publications:

• Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate

• NPTX1 regulates neural lineage specification from human pluripotent stem cells

Undergraduate University: University of Hawaii- Manoa

Undergraduate University: University of Pennsylvania

Undergraduate University: Tufts University

Undergraduate University: University of Michigan- Ann Arbor

Publications:

• REC114 partner ANKRD31 controls number, timing, and location of meiotic DNA breaks. Molecular cell

• Activation of the unfolded protein response via inhibition of protein disulfide isomerase decreases the capacity for DNA repair to sensitize glioblastoma to radiotherapy

• TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling

Undergraduate University: Franklin and Marshall College

Publications

• aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine Ischemia-reperfusion model
• Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
• Development of a multi-sugar LC-MS/MS assay using simple chemical derivatization with acetic anhydride
• Experimental Evidence of a Cyclopropylcarbinyl Conjugative Electronic Effect

• Thermal isomerizations of cis,anti,cis-tricyclo[7.4.0.0(2,8)]tridec-10-ene

Undergraduate University: University of Pennsylvania

Thesis Lab:

Kristy Brown

Undergraduate University: Barnard College

Publications:

• Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells – a novel mechanism for the obesity-breast cancer link
• Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression
• Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice
• Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy
• Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
• Obesity-associated alterations in inflammation, epigenetics
• Metabolic obesity, adipose inflammation and elevated breast aromatase in women with normal body mass index
• Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
• Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Thesis Lab:

Mary Baylies

Undergraduate University: University at Buffalo

Publication:

• Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation

Undergraduate University: The Hebrew University

Undergraduate University: Northeastern University

Publications:

• Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics

• In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

• Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Thesis Lab:

Lorenz Studer

Undergraduate University: Tsinghua University

Publication:

• Lipid deprivation induces a stable intermediate, naïve-to-primed state of pluripotency in human PSC

• High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain

Undergraduate University: University of Southern California

Publications:

• Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells

• Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease

Undergraduate University: University of Chicago

Publications:

• An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.

• Base editing goes into hyperdrive.

• A functional reporter system to identify and enrich base editing activity.

• Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
• Optimized base editors enable efficient editing in cells, organoids and mice.

Undergraduate University: Cornell University

Undergraduate University: Fordham University

• Role of Mitochondria in Ferroptosis

• Aiming at Cancer In Vivo: Ferroptosis-Inducer Delivered by Nanoparticles

• Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signaling

Undergraduate University: MIT University

Undergraduate University: Barnard College

Thesis Lab:

John Petrini

Undergraduate University: Universidad Complutense

Publication:

• Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

Undergraduate University: SASTRA University

Publications:

• Quantitative self-assembly prediction yields targeted nanomedicines.

Undergraduate University: Yeshiva University

Undergraduate University: Shanghai Jiao Tong University

Undergraduate University: Columbia University

Publications:

• Alpha-ketoglutarate links p53 to cell fate during tumor suppression.

• MAGI3-AKT3 fusion in breast cancer amended.

• RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs.

Undergraduate University: Universitat de Barcelona

Thesis Lab:

Frederic Geissman

Undergraduate University: Peking University

Publications:

• Tang Tao Transdermal Delivery of siRNA through Microneedle Array
• Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity

Thesis Lab:

Scott Keeney

Undergraduate University: National Yang Ming University

Thesis Lab:

Chris Lima

Undergraduate University: University of Cambridge

Thesis Lab:

Timothy McGraw

Undergraduate University: Columbia University

Thesis Lab:

Bjorn Kafsack

Undergraduate University: Georg-August-University

Publication:

• Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum
• Single-Cell Transcriptome Profiling of Protozoan and Metazoan Parasites
•  Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites

Thesis Lab:

Danwei Huangfu

Undergraduate University: Harvard University

Publication:

• MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

Thesis Lab:

Morgan Huse

Undergraduate University: New Mexico State University

Thesis Lab:

Alexandra Joyner

Undergraduate University: Boston University

Thesis Lab:

Mary Baylies

Undergraduate University: New College of Florida

Thesis Lab:

Minkui Luo

Undergraduate University: Georgetown University

Thesis Lab:

Ari Melnick

Undergraduate University: Colgate University

Thesis Lab:

John Petrini

Undergraduate University: University of Florida

Thesis Lab:

Charles Sawyer

Undergraduate University: Jilin University

Publications:

• Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation
• Organoid cultures derived from patients with advanced prostate cancer
• PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
• Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth
• Alternative transcription initiation leads to expression of a novel ALK isoform in cancer
• Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC
• SOX2 promotes lineage plasticity and antiandrogen resistance in TP53-and RB1-deficient prostate cancer
• ETV1-positive cells give rise to BRAF^V600E-mutant gastrointestinal stromal tumors
• The cell cycle restricts activation-induced cytidine deaminase activity to early G1
• Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
• FOXF1 defines the core-regulatory circuitry in gastrointestinal stromal tumor (GIST)
• COP1-DET1-ETS axis regulates ERK transcriptional output and modulates sensitivity in MAPK inhibitors

Thesis Lab:

Michael Overholtzer

Undergraduate University: St. John's University

Thesis Lab:

Danwei Huangfu

Undergraduate University: University of California, Berkeley

Thesis Lab:

Alessio Accardi

Undergraduate University: Drew University

Thesis Lab:

Timothy Chan

Undergraduate University: Princeton University

Publication:

• Malignant astrocytic tumor progression potentiated by JAK-mediated recruitment of myeloid cells

Thesis Lab:

Lukas Dow

Undergraduate University:  Beijing University of Technology

Publication:

• Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
• R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine

Thesis Lab:

Luis Parada

Undergraduate University: University of Southern California

Thesis Lab:

Samie Jaffrey

Undergraduate University: Cornell University

Publication:

• In-gel imaging of RNA processing using broccoli reveals optimal aptamer expression strategies

Thesis Lab:

Greg Petsko

Undergraduate University: University of New Haven 

Thesis Lab:

Todd Evans

Undergraduate University: Cornell University

Thesis Lab:

Michael Overholtzer

Undergraduate University: Washington University in St. Louis

Thesis Lab:

Scott Lowe

Undergraduate University: China Agricultural University

Thesis Lab:

Renier Brentjens

Undergraduate University: Peking University

Thesis Lab:

Lewis Cantley

Undergraduate University: National Taiwan University

Thesis Lab:

John Blenis

Undergraduate Univesity: New York University CAS

Thesis Lab:

Lewis Cantley

Undergraduate University: University of California, Irvine

Thesis Lab:

Michel Sadelain

Undergraduate University: Bombay College of Pharmacy

Publication:

• Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Thesis Lab:

John Blenis

Undergraduate University: UC Berkeley

Publication:

• Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer

Thesis Lab:

Sarat Chandarlapaty

Undergraduate University: Colby College

Thesis Lab:

Dirk Remus

Undergraduate University: SUNY, University at Buffalo

Thesis Lab:

Emily Foley

Undergraduate University: VIT University

Thesis Lab:

Marilyn Resh

Undergraduate University: Hunter College

Publication:

• An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine

Thesis Lab:

Timothy Ryan

Undergraduate University: Lahore University of Management Science

Thesis Lab:

Mark Rubin

Undergraduate University: University of Florida

Thesis Lab:

Timothy McGraw

Undergraduate University: University of Notre Dame

Publications:

• SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes
• Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Thesis Lab:

Jennifer Zallen

Undergraduate University: Wellesley College

Publication:

• The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis

Thesis Lab:

David Scheinberg

Undergraduate University: University of California San Diego

Publications:

• Kinase regulation of human MHC class I molecule expression on cancer cells
• T cell receptor mimic antibodies for cancer therapy
• Opportunities and challenges for TCR mimic antibodies in cancer therapy
• A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens
• CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes

Thesis Lab:

John Blenis

Undergraduate University: Korea University

Publications:

• IRE1Œ±-dependent decay of CReP/Ppp1r15b mRNA increases eukaryotic initiation factor 2Œ± phosphorylation and suppresses protein synthesis
• CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
• Loss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis in Ldlr‚àí/‚àí Mice
• Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Thesis Lab:

David Eliezer

Undergraduate University: University of Calcutta

Publication:

• Hedgehog Signaling Pathway Is Active in GBM with GLI1 mRNA Expression Showing a Single Continuous Distribution Rather than Discrete High/Low Clusters, PLoS ONE

Thesis Lab:

Stewart Shuman

Undergraduate University: Lahore University of Management Sciences

Thesis Lab:

Anna Katerina Hadjantonakis

Undergraduate University: Hunter College

Publications:

• A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.

• MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex
• Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression
• Capturing Identity and Fate Ex Vivo: Stem Cells from the Mouse Blastocyst
• Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells
• Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2

Thesis Lab:

Michel Sadelain

Undergraduate University: University of Patras

Publication:

• CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade
• Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Thesis Lab:

Samie Jaffrey

Undergraduate University: KAIST University

Thesis Lab:

Scott Lowe

Undergraduate University: University of Athens

Publications:

• Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
• Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukemia
• DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
• Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

Thesis Lab:

Stewart Shuman

Undergraduate University: Lahore University of Management Sciences

Thesis Lab:

Jennifer Zallen

Undergraduate University: IISER Pune

Thesis Lab:

Jason Butler

Undergraduate University: Stanley Medical College

Publications:

• Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing
• Vascular platform to define hematopoietic stem cell factors and enhance regenerative hematopoiesis
• Endothelial-specific inhibition of NF-Œ∫B enhances functional hematopoiesis
• Regulation of the hematopoietic stem cell lifecycle by the endothelial niche
• Endothelial transplantation rejuvenates aged hematopoietic stem cell function

Thesis Lab:

Ekta Khurana

Undergraduate University: Wuhan University

Publication:

• Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis

Thesis Lab:

Renier Brentjens

Undergraduate University: University of California, Los Angeles

Publications:

• Enhanced fitness of adult spermatogonial stem cells bearing a paternal age-associated FGFR2 mutation

Thesis Lab:

Mary Baylies

Undergraduate University: Vellore Institute of Technology

Publications:

• Imaging Approaches to Investigate Myonuclear Positioning in Drosophila.

Thesis Lab:

Iestyn Whitehouse

Undergraduate University: Moravian College

Publications:

• DNA replication through a chromatin environment.
• Spatiotemporal coupling and decoupling of gene transcription with DNA replication origins during embryogenesis in C. elegans.

Thesis Lab:

Xiaolan Zhao

Undergraduate University: University of North Carolina-Chapel Hill

Publications:

• Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.
• Replication-associated recombinational repair: Lessons from budding yeast.
• Selective modulation of the functions of a conserved DNA motor by a histone fold complex.
• Restriction of replication fork regression activities by a conserved SMC complex.

Thesis Lab:

Ping Chi

Undergraduate University: Peking University

Publications:

• Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth

Thesis Lab:

Cole Haynes

Undergraduate Unversity: Tsinghua University

Publications:

• Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR
• The mitokine quest(ion)
• Mitochondrial dysfunction in cancer

Thesis Lab:

Sarat Chandarlapaty

Undergraduate University: University of Pune

Publication:

• Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

Thesis Lab:

Philipp Niethammer

Undergraduate University: Nankai University

Publication:

• Illuminating Phagocyte Biology

Thesis Lab:

Eric Lai

Undergraduate University: Harvard University

Publications:

• Alteration of miRNA activity via context-specific modifications of Argonaute proteins
• Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila
• Multiple In Vivo Biological Processes Are Mediated by Functionally Redundant Activities of Drosophila mir-279 and mir-996
• Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells
• Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor
• Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals

Thesis Lab:

Richard Kolesnick

Undergraduate University: Boston University

Publication:

• Epigenetic regulation of hematopoietic stem cell development

Thesis Lab:

Eric Lai

Undergraduate University: National Taiwan University

Publications:

•  Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor
• The m6A pathway facilitates sex determination in Drosophila
• Characterization of a TUTase/RNase complex required for Drosophila gametogenesis

Thesis Lab:

Scott Keeney

Undergraduate University: University of Colorado Boulder

Thesis Lab:

Neal Rosen

Undergraduate University: K.C. College, Mumbai University

Thesis Lab:

Todd Evans

Undergraduate University: Harvard University

Publication:

• Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
• ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
• Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
• Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
• Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia
• Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells
• The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

Thesis Lab:

Mary Goll

Undergraduate University: BITS-Pilani-Int.

Thesis Lab:

Heidi Stulhmann

Undergraduate University: R.V. College of Engineering

Publications:

• Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease
• Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease

Thesis Lab:

Alexandra Joyner

Undergraduate University: University of California

Publication:

• Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

Thesis Lab:

Stewart Shuman

Undergraduate University: University of California

Thesis Lab:

Scott Armstrong

Undergraduate University: Tsinghua University

Publication:

• The role of DOT1L in the maintenance of leukemia gene expression

Thesis Lab:

Richard White

Undergraduate University: Sichuan University

Publication:

• Reproducibility of quantitative susceptibility mapping in the brain at two field strengths from two vendors

Thesis Lab:

Stewart Shuman

Undergraduate University: St. Xavier's College

Thesis Lab:

Shahin Rafii

Undergraduate University: Institute of Chemical Technology

Thesis Lab:

Maria Jasin

Undergraduate University:  National Sun Yat-Sen University

Publications:

• ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.
• EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.
• Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks
• Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase.

Thesis Lab:

Dirk Remus

Undergraduate University: Loras College

Publications:

• Chromatin Constrains the Initiation and Elongation of DNA Replication.
• Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.
• Origin plasticity during budding yeast DNA replication in vitro.

Thesis Lab:

Songahi Shi

Undergraduate University: Peking University Health Science Center

Publications:

• PARD3 dysfunction in conjunction with dynamic HIPPO signaling drives cortical enlargement with massive heterotopia

Thesis Lab:

Shahin Rafii

Undergraduate University: Eastern Connecticut State University

Publications:

• Novel biopanning strategy to identify epitopes associated with vaccine protection
• Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration.
• Sox17 drives functional engraftment of endothelium converted from non-vascular cells.

Thesis Lab:

Alexandros Pertsinidis

Undergraduate University: Tsinghua University

Publications:

• Single-Molecule Real-Time 3D Imaging of the Transcription Cycle by Modulation Interferometry

Thesis Lab:

Christopher Park

Undergraduate University: New York Institute of Technology

Publications:

• miR-99 regulates normal and malignant hematopoietic stem cell self-renewal.

Thesis Lab:

Morgan Huse

Undergraduate University: Brandeis University

Publications:

• Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.
• Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells.
• A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Thesis Lab:

Alexandra Joyner

Undergraduate University: Nankai University

Thesis Lab:
Christopher Park

Undergraduate University: University of Tehran

Publications:

• CD99 is a therapeutic target on disease stem cells in myeloid malignancies
• miR-99 regulates normal and malignant hematopoietic stem cell self-renewal

Thesis Lab:

Olga Boudker

Undergraduate University: KAIST University

Publications:

• Binding thermodynamics of a glutamate transporter homolog
• Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

Thesis Lab:

Kathryn Anderson

Undergraduate University: Michigan State University

Thesis Lab: 

Songhai Shi

Undergraduate University: The Chinese University of Hong Kong

Publications:

• Cortical neurogenesis in the absence of centrioles
• SDCCAG8 Regulates Pericentriolar Material Recruitment and Neuronal Migration in the Developing Cortex
• Distinct lineage-dependent structural and functional organization of the hippocampus