BCMB Students: 2013 Entering Class

Thesis Lab:

Dirk Remus

Undergraduate University: SUNY, University at Buffalo

Thesis Lab:

Emily Foley

Undergraduate University: VIT University

Thesis Lab:

Marilyn Resh

Undergraduate University: Hunter College

Publication:

• An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine

Thesis Lab:

Timothy Ryan

Undergraduate University: Lahore University of Management Science

Thesis Lab:

Mark Rubin

Undergraduate University: University of Florida

Thesis Lab:

Timothy McGraw

Undergraduate University: University of Notre Dame

Publications:

• SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes
• Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Thesis Lab:

Jennifer Zallen

Undergraduate University: Wellesley College

Publication:

• The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis

Thesis Lab:

David Scheinberg

Undergraduate University: University of California San Diego

Publications:

• Kinase regulation of human MHC class I molecule expression on cancer cells
• T cell receptor mimic antibodies for cancer therapy
• Opportunities and challenges for TCR mimic antibodies in cancer therapy
• A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens
• CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes

Thesis Lab:

John Blenis

Undergraduate University: Korea University

Publications:

• IRE1Œ±-dependent decay of CReP/Ppp1r15b mRNA increases eukaryotic initiation factor 2Œ± phosphorylation and suppresses protein synthesis
• CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
• Loss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis in Ldlr‚àí/‚àí Mice
• Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Thesis Lab:

David Eliezer

Undergraduate University: University of Calcutta

Publication:

• Hedgehog Signaling Pathway Is Active in GBM with GLI1 mRNA Expression Showing a Single Continuous Distribution Rather than Discrete High/Low Clusters, PLoS ONE

Thesis Lab:

Stewart Shuman

Undergraduate University: Lahore University of Management Sciences

Thesis Lab:

Anna Katerina Hadjantonakis

Undergraduate University: Hunter College

Publications:

• A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.

• MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex
• Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression
• Capturing Identity and Fate Ex Vivo: Stem Cells from the Mouse Blastocyst
• Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells
• Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2

Thesis Lab:

Michel Sadelain

Undergraduate University: University of Patras

Publication:

• CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade
• Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Thesis Lab:

Samie Jaffrey

Undergraduate University: KAIST University

Thesis Lab:

Scott Lowe

Undergraduate University: University of Athens

Publications:

• Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
• Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukemia
• DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
• Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer

Thesis Lab:

Stewart Shuman

Undergraduate University: Lahore University of Management Sciences

Thesis Lab:

Jennifer Zallen

Undergraduate University: IISER Pune

Thesis Lab:

Jason Butler

Undergraduate University: Stanley Medical College

Publications:

• Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing
• Vascular platform to define hematopoietic stem cell factors and enhance regenerative hematopoiesis
• Endothelial-specific inhibition of NF-Œ∫B enhances functional hematopoiesis
• Regulation of the hematopoietic stem cell lifecycle by the endothelial niche
• Endothelial transplantation rejuvenates aged hematopoietic stem cell function

Thesis Lab:

Ekta Khurana

Undergraduate University: Wuhan University

Publication:

• Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis

Thesis Lab:

Renier Brentjens

Undergraduate University: University of California, Los Angeles

Publications:

• Enhanced fitness of adult spermatogonial stem cells bearing a paternal age-associated FGFR2 mutation