Research
Patients with autoimmune disease, such as rheumatoid arthritis, were often excluded from clinical trials for immune checkpoint inhibitors (ICI). Information on overall survival, immune related adverse events (irAEs), and treatment of irAEs on ICI treated autoimmune patients is needed to inform both clinicians and patients. To gain insight on these outcomes, I use large datasets, to study the disease course for ICI treated cancer patients with autoimmune disease. Additionally, I use a variety of statistical methods, such as survival analyses (landmark, time dependent covariates) and machine learning methods (random survival forests, survival classification and regression trees) in my research.
Current projects
Overall survival among immune checkpoint inhibitor treated Rheumatoid Arthritis Patients with cancer
Steroid and disease modifying anti-rheumatic drug use among immune checkpoint inhibitor treated Rheumatoid Arthritis Patients with cancer
Immune related adverse events among autoimmune patients with cancer treated with immune checkpoint inhibitors
Bio
I am an Assistant Scientist at the Hospital for Special Surgery (HSS), and an Assistant Professor of Epidemiology in the Department of Medicine at Weill Cornell Medical College. I graduated from Emory University with a Bachelor of Science Degree in Biology and a Masters of Science in Public Health in Epidemiology and I received my Doctorate in Public Health from the State University of New York Downstate Medical Center. My educational background is in epidemiology and I have a broad background in various biostatistical methods including analysis of large administrative datasets, survival analysis, machine learning methods (LASSO, random forest, random survival forest, classification and regression trees, etc), meta-analyses, hierarchical models and qualitative analyses. I divide my time between being a biostatistician on rheumatology research projects and being a PI on my own Immune Checkpoint Inhibitor research.
Distinctions
Discovered and named a new bacteria species, Nocardia mikamii
Awarded the HSS Department of Medicine Discovery Grant in 2023 and had funding renewed in 2024
American College of Rheumatology and European Alliance of Associations for Rheumatology, Research Exchange Program participant, Vienna, Austria 2024
Selected publications
Incidence of checkpoint inhibitor-associated inflammatory arthritis, immunomodulation and mortality in cancer patients on immunotherapy: a retrospective cohort study.
Bass AR, Xie F, Jannat-Khah D, Ghosh N, Chan KK, Saxena A, Curtis JR. Rheumatology (Oxford). 2024 Jun 18:keae343. doi: 10.1093/rheumatology/keae343. Online ahead of print. PMID: 38889288
Comparative safety and effectiveness of TNF inhibitors, IL6 inhibitors and methotrexate for the treatment of immune checkpoint inhibitor-associated arthritis.
Bass AR, Abdel-Wahab N, Reid PD, Sparks JA, Calabrese C, Jannat-Khah DP, Ghosh N, Rajesh D, Aude CA, Gedmintas L, MacFarlane L, Arabelovic S, Falohun A, Mushtaq K, Haj FA, Diab A, Shah AA, Bingham CO, Chan KK, Cappelli LC. Ann Rheum Dis. 2023 Jul;82(7):920-926. doi: 10.1136/ard-2023-223885. Epub 2023 Apr 5. PMID: 37019614
Depressive symptoms do not discriminate: racial and economic influences between time-varying depressive symptoms and mortality among REGARDS participants.
Jannat-Khah DP, Khodneva Y, Bryant K, Ye S, Richman J, Shah R, Safford M, Moise N. Ann Epidemiol. 2020 Jun;46:31-40.e2. doi: 10.1016/j.annepidem.2020.04.004. Epub 2020 May 7. PMID: 32451197
Treating loss-to-follow-up as a missing data problem: a case study using a longitudinal cohort of HIV-infected patients in Haiti.
Jannat-Khah DP, Unterbrink M, McNairy M, Pierre S, Fitzgerald DW, Pape J, Evans A. BMC Public Health. 2018 Nov 19;18(1):1269. doi: 10.1186/s12889-018-6115-0. PMID: 30453995
Nocardia mikamii sp. nov., isolated from human pulmonary infections in the USA.
Jannat-Khah D, Kroppenstedt RM, Klenk HP, Spröer C, Schumann P, Lasker BA, Steigerwalt AG, Hinrikson HP, Brown JM. Int J Syst Evol Microbiol. 2010 Oct;60(Pt 10):2272-2276. doi: 10.1099/ijs.0.015594-0. Epub 2009 Nov 13. PMID: 19915112