For COVID-19 vaccine updates, please review our information guide. For patient eligibility and scheduling availability, please visit VaccineTogetherNY.org.

Yueming Li

Professor

Biography

The main interests of my laboratory are to elucidate the mechanism of γ-secretase-dependent Notch signaling and amyloid precursor protein (APP) processing under physiological and pathological conditions and to develop target-based therapies. γ-Secretase represents a novel class of proteases that catalyze proteolysis of substrates within the transmembrane domain, an apparently hydrophobic environment, wherein water is required for peptide hydrolysis. Intramembranous proteases, including γ-secretase, site 2 proteases, rhomboids and signal peptide peptidase, play an essential role in many biological processes ranging from sterol regulation to development. Unraveling the intricacies of these enigmatic proteases is a formidable challenge that requires novel insights and approaches.

Research Topics

Ready to start?
Apply now
Need more info?
Ask a question
Follow us on
Instagram

Weill Cornell Medicine Graduate School of Medical Sciences 1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-5981