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The overall long-term goal of the laboratory is to study mechanisms of neurodegeneration in Alzheimer’s Disease, Huntington’s Disease, Parkinson’s Disease and amyotrophic lateral sclerosis, and to devise therapeutic strategies in mouse models of neurodegenerative diseases by combining genetic and pharmacologic approaches to improve mitochondrial function and attenuate oxidative damage. In our laboratory, we test new neuroprotective agents in animal models of neurodegenerative diseases including Alzheimer’s disease, Huntington’s disease and Parkinson’s disease. These studies will help us understand the role of mitochondrial dysfunction and oxidative damage in the pathogenesis of neurodegenerative diseases. Another goal is to further develop novel neurochemical assays for assessing oxidative damage for use in clinical trials of new therapies for these diseases. Finally, our laboratory aims to gain knowledge of mitochondrial biology in different cell types to determine whether mitochondrial function is related to cell-type specificity in neurodegenerative diseases. Our studies may contribute to developing new therapies for the treatment of human neurodegenerative diseases.