Research
The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized magnetic resonance, allowing us the ability to bring these approaches to the clinic.
Figure 1.
Current Projects:
- Metabolic dynamics
- Advanced metabolic imaging
- Metabolic engineering
- Cell based therapies
Bio
Kayvan R. Keshari earned his bachelor’s degree in MCB-Biochemistry and Applied Mathematics from the University of California, Berkeley in 2003 followed by a PhD in Biomedical Engineering from the University of North Carolina, Chapel Hill in 2009. He was appointed as an Assistant Member and Assistant Professor at Memorial Sloan Kettering Cancer Center in 2013. He now is Member and Professor and holds the Fred Lebow Chair.
Selected Publications:
DeBerardinis, R. J., & Keshari, K. R. (2022). Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell, 185(15), 2678–2689. https://doi.org/10.1016/j.cell.2022.06.029
Tee, S. S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R. M., Chirayil, R., Jeong, S., Shakiba, M., Kastenhuber, E. R., Chen, S., Sigel, C., Lowe, S. W., Jarnagin, W. R., Thompson, C. B., Schietinger, A., & Keshari, K. R. (2022). Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances, 8(14), eabm7985. https://doi.org/10.1126/sciadv.abm7985
Jeong, S., Savino, A. M., Chirayil, R., Barin, E., Cheng, Y., Park, S. M., Schurer, A., Mullarky, E., Cantley, L. C., Kharas, M. G., & Keshari, K. R. (2021). High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. Cell metabolism, 33(1), 145–159.e6. https://doi.org/10.1016/j.cmet.2020.12.005
Granlund, K. L., Tee, S. S., Vargas, H. A., Lyashchenko, S. K., Reznik, E., Fine, S., Laudone, V., Eastham, J. A., Touijer, K. A., Reuter, V. E., Gonen, M., Sosa, R. E., Nicholson, D., Guo, Y. W., Chen, A. P., Tropp, J., Robb, F., Hricak, H., & Keshari, K. R. (2020). Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell metabolism, 31(1), 105–114.e3. https://doi.org/10.1016/j.cmet.2019.08.024
Jeong, S., Eskandari, R., Park, S. M., Alvarez, J., Tee, S. S., Weissleder, R., Kharas, M. G., Lee, H., & Keshari, K. R. (2017). Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Science advances, 3(6), e1700341. https://doi.org/10.1126/sciadv.1700341