“The main interest of the lab is centered on the understanding of nucleic acid recognition in the context of autoimmunity and in particular on the potential clinical benefit of interfering with TLR signaling in human diseases. We are using both human and mouse approaches and have been focusing on the impact that the recognition of self nucleic-acid by TLR7, TLR8, and TLR9 has on end-organ damage with a particular interest in the skin. The lab is also interested in how the skin micro-environment can impact cellular responses, with a focus on pDCs, both in normal and pathogenic situations. Most projects benefit from close collaborations with clinicians from the hospital who provides samples and expertise.”
