Graduate School of Medical Sciences
A partnership with the Sloan Kettering Institute

Antonio Marzio

Assistant Professor
Dr. Marzio Headshot
The focus of the Marzio laboratory is to elucidate how deregulation of the ubiquitin-proteasome system (UPS) promotes cancer progression, with a particular emphasis on the DNA damage response (DDR) and antitumor immunity.


The focus of the Marzio laboratory focus lies in understanding the role of the ubiquitin-proteasome system (UPS) and how its deregulation influences the development of cancer, particularly in relation to the DNA damage response (DDR) and antitumor immunity.  To date, despite the rapid increase in interest in the role of the UPS in regulating immune responses, there has been rather limited progress in understanding how deregulation of E3 ubiquitin ligases (E3s) participate in antitumor immunity To address these questions, we use multidisciplinary approaches including biochemistry, cell signaling, mouse models of tumorigenesis, and pharmacotherapy The ultimate goal of these efforts is to understand the underlying molecular drivers of tumorigenesis in order to leverage these genetic and biochemical alterations for therapeutic applications. 

The Marzio lab has recently identified a molecular mechanism by which deregulation of the E3 ubiquitin ligase KEAP1 controls fundamental aspects of anti-tumor immunity and DDR in the context of non-small cell lung cancer (NSCLC) (Marzio et al., Cell 2022). Understanding the role of KEAP1, and its substrates, has the potential to have a profound impact on our understanding of the immune response NSCLC, and to improve the success of therapy for this tumor type. The laboratory also studies how overexpression of the chromatin regulator EMSY modulates DDR pathways, and how this contributes to tumorigenesis. 

Current projects 

  • The role of the tumor suppressor KEAP1 in antitumor immunity 
  • UPS components activity in innate immunity (and tumor immunosurveillance) 
  • The oncogenic activity of EMSY in cancer development and progression 


Dr. Antonio Marzio achieved his bachelor's degree in Biology in 2009, followed by a master's degree in Genetics and Molecular Biology in 2010, and ultimately, his PhD in Medical Genetics in 2014. These academic accomplishments were earned at "SAPIENZA" University of Rome (Italy) while being mentored by Maurizio Gatti. Subsequently, in 2014, Dr. Marzio joined the Biochemistry and Molecular Pharmacology Department at NYU Langone Health as a postdoctoral fellow, under the guidance of Michele Pagano. In 2022, Dr. Marzio was appointed Assistant Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College. 


  • American-Italian Cancer foundation Fellowship (2022) 
  • Member of F1000-Faculty of 1000 (2016). 
  • AIRC-Marie Curie Institute Fellowship (2016-2018) 
  • American-Italian Cancer foundation Fellowship (2014-2016) 
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