I have had a long-standing interest the Wnt family of signaling proteins and their role in cancer, beginning soon after the first Wnt gene was discovered as a mammary oncogene in mice. Our research centered on mechanistic aspects of Wnt signaling pathways and how they contribute to tissue development, homeostasis, hyperplasia, and cancer. Mechanistic studies have included the demonstration that phosphorylation of Dishevelled is a consistent manifestation of non-canonical Wnt signaling independent of beta-catenin, and serves as a robust assay for such signals. We have worked with cells in culture, organoids, mouse models of breast and colorectal cancer, as well as patient-derived material. The role of stem-like cells in tumorigenesis has been of particular interest, as well as other aspects of how aberrant Wnt signaling contributes to cancer.
- Collaborations with other investigators
Anthony Brown obtained an undergraduate degree in Natural Sciences (Genetics) from the University of Cambridge in 1977 and a PhD in Molecular Biology from the University of Edinburgh in 1982. He was a postdoctoral fellow with Pierre Chambon in Strasbourg, France, and subsequently with Harold Varmus at the University of California, San Francisco. He joined the faculty at Weill Cornell in 1987. He is currently Director of the Office of Medical Student Research.
- Royal Society European Science Exchange Fellowship
- Medical Research Council (U.K.) Travelling Fellowship
- Cornell Scholars Award
- Andrew W. Mellon Teacher-Scientist Award
- Pew Scholar in the Biomedical Sciences
- Irma T. Hirschl Career Scientist Award
- WCM Awards for Teaching Excellence
- WCM Awards for Excellence in Medical Education