This course provides an overview of bacterial, protozoan, and metazoan pathogens, and the diverse mechanisms by which they elicit disease in humans. Select topics will also be presented on the evolution and diversity of cellular and genetic systems in human pathogens. The course includes a discussion of pathogen immune evasion strategies and will therefore assume Fundamental Immunology as a pre-requisite or concurrent course.
Infectious diseases continue to be a leading cause of human morbidity and mortality worldwide as well as an important cause of economic loss and the ‘poverty trap’ in developing countries. Microbial Pathogenesis focuses on the molecular mechanisms of host-pathogen interactions and pathogenesis of representative bacterial, fungal, and protozoan diseases. Topics include malaria, trypanosomiasis, toxoplasmosis, selected gram-negative and gram-positive bacterial infections, pathogenic mycobacteria, opportunistic mycoses, the evolution of pathogenicity, and the impact of the host microbiota during microbial pathogenesis, and the development of antimicrobials and vaccines. The course is taught by Rockefeller and Cornell faculty and selected guest speakers. Each class includes a lecture followed by an in-depth discussion of assigned papers with the lecturer. The discussion can be continued at lunch with the speaker.
Each class includes a lecture, followed by one or two (depending on the number of students) 20- minute presentations by students on a paper suggested by the speaker in which they outline follow-up experiments. Lunch with the speaker follows for a set of interested students. Course requirements include attendance, participation in the discussions, individual presentations, and a three-page research proposal at the end of the course.
Course Directors: Luciano Marraffini and Jeremy Rock
Drs. Marraffini and Rock will offer Microbial Pathogenesis in Spring 2022.
Stay tuned for the Microbial Pathogenesis course syllabus.
Dates: March 4– June 17, 2022
Day/Time: Fridays from 10 am -12:00 pm
Location: Carson Auditorium