Research
The current interest of our team is to elucidate the links between cellular pathways of response to stress – including (but not limited to) autophagy, cellular senescence and multiple variants of regulated cell death – and the preservation of organismal homeostasis, with a particular focus on anticancer immunity. More specifically, we are interested in dissecting the complexity of the tumor microenvironment with respect to the mechanisms through which malignant as well as non-malignant components of the tumor exposed to chemotherapy, radiation therapy and immunotherapy emit danger signals that are involved in the initiation and perpetuation of robust immune responses. The detailed characterization of these molecular and cellular circuitries may identify stress-responsive mechanisms of adaptation in malignant or non-malignant cells as novel targets for the pharmacological manipulation of anticancer immune responses. Ultimately, these findings may translate into novel clinical studies based on combinatorial therapeutic regimens aimed at maximizing immunostimulation within the tumor microenvironment.
Figure 1
Current Projects:
- Role of the mitochondrial immune checkpoint in the immunogenicity of radiation
- Immunological mechanisms of resistance to CDK4/CDK6 inhibitors in breast cancer
- Mechanisms of resistance to pembrolizumab in breast cancer
- Targeting the cancer stem cell/MDSC interaction
Bio
Prior to joining Weill Cornell Medical College as an Assistant Professor of Cell Biology in Radiation Oncology with the Department of Radiation Oncology (2017), Lorenzo Galluzzi (born in 1980) was a Junior Scientist of the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2012-2016). Lorenzo Galluzzi did his post-doctoral training at the Gustave Roussy Comprehensive Cancer Center (Villejuif, France; 2009-2011), after receiving his PhD from the University Paris Sud (Le Kremlin-Bicetre, France; 2005-2008) and his MSc from the University of Modena and Reggio Emilia (Modena, Italy, 1999-2004).
Distinctions:
- 2021-2022 Highly Cited Researcher in Immunology, Molecular Biology & Genetics and Pharmacology/Toxicology (Clarivate Analytics)
- SITC 2021 Team Science Award, Team Member (SITC)
- 2021 Immuno-Oncology Distinguished Young Investigator Research Award, 1st Runner Up (IOYIF)
- 2019-2020 Highly Cited Researcher in Immunology and Molecular Biology & Genetics (Clarivate Analytics)
- Associate Director, European Academy for Tumor Immunology
- Editor in Chief of Oncoimmunology, International Review of Cell Biology, Methods in Cell Biology, and Molecular & Cellular Oncology
- Section or Associate Editor of Journal of Translational Medicine, Cell Death and Disease, iScience, Microbial Cell, Cell Stress, Cell Communication and Signaling and Pharmacological Research