The Imielinski lab applies cancer genome assembly to study long range DNA structure in tumors. A key goal of the lab is to understand how complex somatic DNA rearrangements shape the tumor epigenome and drive cancer progression. More fundamentally, the lab is interested in using structural variation as a lens to study genomic plasticity and somatic evolution. The lab is committed to translating clinically relevant basic research findings into genomic diagnostics and incorporating these into precision cancer care.
