Research
Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host disease with a high fundamental and translational impact. His work also identified specialized stromal niches that represent the critical sources of Notch ligands in secondary lymphoid organs, sparking a new interest in the biology of lymphoid tissue fibroblastic reticular cells in immune and hematologic disorders. Ongoing projects in the laboratory build on these discoveries to explore the role of Notch signaling in immune cell function and malignant transformation.
Current Pojects:
- Notch signaling in graft-versus-host disease
- Notch signaling in anti-cancer immunity
- Role of Notch in T follicular helper responses
- Oncogenic Notch signals in T-cell lymphomas
- Immunobiology of lymph node fibroblastic reticular cells
Bio
Dr. Maillard is a physician-scientist who earned his MD at the University of Lausanne, Switzerland, and his PhD in immunology from the University of Lausanne and the Swiss Academy of Medical Sciences under the mentorship of Dr. Heidi Diggelman. He completed a residency in Internal Medicine at the University Hospital of Lausanne, followed by a fellowship in Hematology-Oncology and post-doctoral fellowship in immunology at the University of Pennsylvania with Dr. Warren Pear. He started his independent career at the University of Michigan in 2007 where he rose through the ranks before joining the University of Pennsylvania in 2018 as a Professor of Medicine and Vice-Chief for Research in the Division of Hematology/Oncology. In 2024, Dr. Maillard was recruited to Memorial Sloan Kettering Cancer Center as Head of the Division of Hematologic Malignancies.
Distinctions:
- Member, Association of American Physicians (2024)
- Interurban Clinical Club (2019)
- DuPont Guerry, IV, MD Award for Outstanding Mentorship, University of Pennsylvania Perelman School of Medicine (2019)
- League of Research Excellence, University of Michigan Medical School (2014)
- Member, American Society of Clinical Investigation (2013)
Selected publications:
Tran IT, Sandy AR, Carulli AJ, Ebens C, Chung J, Shan GT, Radojcic V, Friedman A, Gridley T, Shelton A, Reddy P, Samuelson LC, Yan M, Siebel CW, Maillard I. Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest, 123(4): 1590-1604, 2013. PMCID: PMC3613915
https://pubmed.ncbi.nlm.nih.gov/23454750/
Chung J, Ebens CE, Perkey E, Radojcic V, Koch U, (…), Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest, 127(4): 1574-88, 2017. PMCID: PMC5373885
https://pubmed.ncbi.nlm.nih.gov/28319044/
Gómez Atria D*, Gaudette BT*, Londregan J*, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel CW, Ryan RJH, Robertson TF, Burkhardt JK, Pear WS, Allman D**, Maillard I**. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naïve B cells. J Clin Invest, 2022 Jul 1;132(13):e158885. doi: 10.1172/JCI158885. PMCID: PMC9246379
https://pubmed.ncbi.nlm.nih.gov/35579963/
Tkachev V*, Vanderbeck A*, Perkey E*, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Burbach B, Shimizu Y, Panoskaltsis-Mortari, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS**, Maillard I**. Notch signaling drives intestinal graft-versus-host disease in mice and non-human primates. Science Translational Medicine 15(702):eadd175, 2023. PMID: 37379368
https://pubmed.ncbi.nlm.nih.gov/37379368/
Allman A*, Gaudette BT*, Kelly S*, Alouche N*, Carrington L, Perkey E, Brandstadter JD, Outen R, Vanderbeck A, Lederer K, Zhou Y, Faryabi RB, Robertson TF, Burkhardt JK, Tikhonova A, Aifantis I, Scarpellino L, Koch U, Radtke F, Lütge M, De Martin A, Ludewig B, Tveriakhina L, Gossler A, Mosteiro L, Siebel CW, Gómez Atria D, Luther SA, Allman D**, Maillard I**. Splenic fibroblasts control marginal zone B-cell movement and function via two distinct Notch2-dependent regulatory programs. Immunity 2025. Jan 14;58(1):143-161.e8. doi: 10.1016/j.immuni.2024.12.003. PMCID: PMC11735314