The purpose of this seminar is to review and critically evaluate the philosophical underpinnings of current guidelines and regulations for the responsible conduct of research. It considers different aspects of doing research where moral decision-making is necessary. Investigators’ responsibilities as members of the scientific community and gatekeepers of public trust in science are discussed. Topics include ethical questions related to the research process, professional integrity, authorship, and respect for human subjects. Case studies are used. By the end of the course, students should be able to rigorously follow principles of responsible conduct of research.