Cryoelectron Microscopy of Macromolecular Assemblies

This course, which is held on the premises of the New York Structural Biology Center, will cover the theory and practice of solving molecular structures by electron microscopy. It blends a series of lectures from local experts followed by student-led discussion sessions with practical sessions that parallel the topics introduced during the lectures. The course first covers optics, sample preparation and a basic mathematical description of diffraction before moving into a detailed exploration of the three main methods of structure determination: tomography, single particle analysis and 2D crystallography. The course ends with a discussion of map interpretation and molecular fitting.

Elective for Year 3 and above, offered at the New York Structural Biology Center.

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Weill Cornell Medicine Graduate School of Medical Sciences 1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-5981