Graduate School of Medical Sciences

You are here

Yueming Li

Professor

The main interests of my laboratory are to elucidate the mechanism of γ-secretase-dependent Notch signaling and amyloid precursor protein (APP) processing under physiological and pathological conditions and to develop target-based therapies. γ-Secretase represents a novel class of proteases that catalyze proteolysis of substrates within the transmembrane domain, an apparently hydrophobic environment, wherein water is required for peptide hydrolysis. Intramembranous proteases, including γ-secretase, site 2 proteases, rhomboids and signal peptide peptidase, play an essential role in many biological processes ranging from sterol regulation to development. Unraveling the intricacies of these enigmatic proteases is a formidable challenge that requires novel insights and approaches.

Research Topics

Ready to start?
Apply now
Need more info?
Ask a question

Weill Cornell Medicine
Graduate School of Medical Sciences
1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-5981