Assistant Professor of Computational Biology in Cardiothoracic Surgery
The broad goals of the research in the Wang lab are to understand: How epigenetics regulates transcriptome and How transcriptional shifts affect cell states and cell/tissue level phenotypes
The broad goals of the research in the Wang lab are to understand: How epigenetics regulates transcriptome and How transcriptional shifts affect cell states and cell/tissue level phenotypes. To achieve our goal, we are motivated by modulating the causes of transcriptional shifts and the translational potential of identifying.
We develop and apply computational tools to integrate and interpret large biomedical and molecular datasets that can uncover the regulation mechanism and the effects of the transcriptional process. Specifically, we aim to utilize high-throughput multi-omics datasets, mostly based on DNA and RNA sequencing, to develop models that explain how cell state is regulated.
We are especially interested in endothelial cells (ECs), covering various aspects of their biology, such as their differentiation and trans-differentiation, and the stability/plasticity of their chromatin structure and histone modification.
Biography
Dr. Guangyu Wang is an Assistant Professor of Cardiovascular Sciences at Houston Methodist Research Institute (HMRI), Weill Cornell Medical College. He started his research group in July of 2021. The overarching goal of his research is to utilize high-throughput multi-omics datasets, mostly based on DNA and RNA sequencing, to develop models that explain how cell state is regulated.
He is especially interested in endothelial cells (ECs), covering various aspects of their biology, such as their differentiation and transdifferentiation, and the stability/plasticity of their chromatin structure and histone modification.
