What does PBSB look for in student applicants?
We welcome applications from any individual who values the use and development of quantitative experimental, computational, and theoretical approaches for tackling challenging biological problems of medical relevance. Applicants should have demonstrated excellence and intellectual ambition in their previous coursework. We also expect that applicants will have had at least one significant research experience.
Our most successful applicants will have had meaningful exposure to and demonstrated aptitude for biochemical principles, molecular biology, chemistry, physics, statistics, calculus, linear algebra, and coding (Python, C, Matlab, R, or similar), either through formal coursework, research, or independent study.
Furthermore, within the integrative construct of the PBSB program, there are two areas of concentration: Bioinformatics, which emphasizes how biological information is expressed and organized, and Biophysics, which emphasizes how biological information is generated and processed. Therefore, we recommend that applicants interested in Bioinformatics (Stream A) have had some exposure to machine learning and that those interested in Biophysics (Stream B) are adept with differential equations. During the application process, you will indicate which Stream you are most interested in; this decision influences your course selections, but you will be able to take courses from both Streams (and during the second year, we encourage students to take electives from the Stream that is not their central focus).
See Apply Online for application deadline, procedures, and requirements.
The path to the degree
The program of study consists of didactic courses, seminars and supervised research leading to the preparation of a thesis. Each student works with first-year advisors to design an individualized program of study that reflects his/her specific background and interests. Regularly scheduled meetings with faculty ensure that the student's educational program progresses as planned.
Classroom education during the first two years consists of core courses, seminar course series, a responsible conduct of research course and electives. In the first year, formal coursework is complemented by participation in journal clubs, as well as laboratory rotations. For information about PBSB program courses, see Curriculum.
During the first year, students rotate in three different labs to explore different possibilities for their research project. By July of the first year, each student selects a thesis lab and major sponsor (thesis advisor). Once they choose their thesis lab, the student selects two additional Graduate School faculty advisors who can contribute their expertise to the student’s project. The thesis advisor and these two additional faculty form the Special Committee, which meets at least once a year to discuss research progress and future directions with the student. The Special Committee also serves as the core group of examiners for the student's Admission to Candidacy Exam (ACE) and thesis defense examination.
The ACE consists of two parts: a written exam in the form of an NIH R01 proposal, and an oral exam, which includes discussion of the written research proposal. Students are expected to take this exam by July of their second year. The exam provides an opportunity for students to demonstrate that they have attained the requisite breadth of knowledge to continue in the PhD program and are prepared to undertake full-time thesis research.
After completing the ACE, the student's annual (or more frequent) meetings with the Special Committee provide the forum for the student to report on his/her progress and agree upon future research directions.
Thesis research is typically completed within four to six years, under the direction of the student's sponsor. The Special Committee advises the student in his/her research and oversees development of the thesis. During this time the student continues to participate as a student within the PBSB Program but works full-time in his/her thesis laboratory.
The culmination of the student's successful progression through the program is the final examination (the "defense") and certification by the Special Committee that the thesis represents an official piece of research that satisfies the requirements of the Graduate School for a PhD degree.