My laboratory is interested in how epigenetic information shapes vertebrate development. The acquisition of cellular identity relies on a combination of genetic and epigenetic information. Genetic information encodes the transcription factors and effector genes that drive differentiation. Epigenetic information shapes the accessibility of transcription factors to DNA, providing a heritable chromatin landscape that can direct or reinforce cell-type specific transcription programs. While the general importance of epigenetic regulation is clear, we still have much to learn about how specific mechanisms contribute to development, particularly in vertebrate species. Moreover, it is now well established that the epigenetic landscape of cancer cells differs significantly from primary tissues. An increased knowledge of how the epigenetic landscape is regulated during normal development will be essential for understanding how its deregulation contributes to malignancy.