Graduate School of Medical Sciences

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Critical Analysis of the Scientific Literature in Pharmacology

This course focuses on the underlying logic behind the design of scientific experiments. An emphasis is placed on understanding how hypotheses are generated and how variables, assays, rationales and model building are utilized in experimental design. Each class focuses on a recent paper in scientific literature and uses the paper as a starting point for discussion. Students are expected to propose and justify novel experiments based on the paper and discussion. Students are encouraged to use "Protocols in Molecular Biology," as well as other resources to become familiar with the methodology, advantages and limitations of the experimental approaches used in the papers. It is expected that students will have to read background papers for each of the papers discussed in class.

Elective - From Bench to Bedside: Business Fundamentals for Entrepreneurial Scientists

"From Bench to Bedside," hosted by the Bench to Bedside Initiative and the Sanders Triā€Institutional Therapeutics Discovery Institute, Inc., teaches basic financial analysis and principles of entrepreneurship. Lectures will cover the process of evaluating the market potential of a technology, building basic financial models, funding mechanisms, and writing and presenting a business plan to potential investors. Lectures are open to members of Cornell University, Memorial Sloan Kettering Cancer Institute and Rockefeller University. We welcome leaders in the local NYC healthcare and biotechnology sector to participate.

Neuropharmacology I: Genes, Drugs and Behavior

This course is jointly sponsored by the Neuroscience and Pharmacology Programs. It is designed to present current concepts of the major central nervous system (CNS) neurotransmitters and their functional neuroanatomy. The course will integrate discussions of the mechanisms of neurotransmitter biosynthesis and release, receptor signal transduction and the alterations produced by CNS drugs.

Neuropharmacology II: Neuropeptides, Pain and Drugs of Abuse

The Neuropharmacology II course focuses on signaling by neuropeptides, opioid receptors, mechanisms of pain management and drugs of abuse.

Pharmacology Seminar Series

The Pharmacology Seminar Series is a series of presentations by invited speakers from universities and the pharmaceutical industry discussing topics of importance in the broad field of pharmacology. These topics include both scientific and policy presentations. Students may choose to have lunch with the speaker to discuss a wide range of topics in an informal atmosphere. In addition, each student meets as part of a small group with one speaker after the seminar to further discuss the selected topic.

Principles of Clinical Pharmacology

This course is designed to present basic principles for understanding the rationale behind development of drug therapy with consideration of the factors involved in individual variability, pharmacokinetics and pharmacogenomics. Topics will include: dose-response, drug efficacy and potency, drug absorption, distribution, metabolism and excretion, the effects of liver and kidney disease on dose-response, drugs in the young, the elderly and pregnancy. In addition, guest lecturers from industry and the FDA will discuss drug development from their respective points of view.

Principles of Pharmacology I: Chemical Biology

Chemical biology is a diverse and evolving field involving chemical approaches to studying and manipulating biological systems. In this course, students will develop an understanding of chemical reactions used in the synthesis and biosynthesis of small molecules and macromolecules, and of the chemical principles that underlie enzyme function and receptor pharmacology. These topics are at the core of modern molecular pharmacology and are essential to understanding how drugs are currently developed in the pharmaceutical industry. At the end of the course students give an oral presentation on a current topic of their choosing in chemical biology.

Principles of Pharmacology II: Signal Transduction

The goal of the Signal Transduction Module is to provide students with an understanding of the basic recurring themes in cell signaling mechanisms and to familiarize the students with a majority of the key signal transduction pathways. The course comprises approximately 30 lectures, each 1.5 hours in length. An emphasis is placed on: 1) the use of pharmacologic and chemical tools to study problems in signal transduction; and 2) structural insights into signaling mechanisms based on x-ray, NMR and computational approaches. By the end of the course students feel comfortable reading and comprehending journal articles related to the latest findings in signal transduction.

Principles of Pharmacology III: Principles and Systems Pharmacology

The Systems Pharmacology Module occupies the third quarter of the year-long Introduction to Pharmacological Principles. The 9 week course is arranged into three modules: 5 sessions in the first module cover general pharmacological principles, 9 sessions in the second module focus on nervous and circulatory systems, and 10 sessions in the third and final module cover host defense and renal and endocrine systems. An understanding of systems pharmacology is necessary and valuable for all Pharmacology graduate students.

Principles of Pharmacology IV: Cancer Pharmacology

This course focuses on the principles and applications of modern cancer therapeutic approaches. Lecture topics range from traditional cytotoxic and anti-mitotic agents, to natural products and their chemistry, to biology and immunologic therapies, to rationally designed targeted small molecule inhibitors. Basic principles underlying mechanisms of cancer cell death, angiogenesis, and radiobiology and imaging are also covered. Cancer stems cells and therapeutic approaches focused on cancer stem cells are also discussed.

Responsible Conduct of Research

The objectives of this course are to: heighten students' awareness of ethical considerations relevant to the conduct of research; inform students of federal, state and institutional policies, regulations and procedures; and provide students with critical analysis and problem solving skills for ethical decision-making.

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Weill Cornell Medicine
Graduate School of Medical Sciences
1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-5981