BCMB Students: 2018 Entering Class

Undergraduate University: University of Nottingham 

Undergraduate University: Northeastern University

Publications:

• Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2
• Gating choreography and mechanism of the human proton-activated chloride channel ASOR.

Undergraduate University: New York University

Publications:

• CRISPR in cancer biology and therapy

• Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

• GO: a functional reporter system to identify and enrich base editing activity

• Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition

• Tankyrase inhibition sensitizes cells to CDK4 blockade
• Identification of cancer drivers at CTCF insulators in 1,962 whole genomes

• Pressure and Stretch Differentially Affect Proliferation of Renal Proximal Tubular Cells”

Undergraduate University: University of Newcastle

Undergraduate University: Northeastern University

Publications:

• A non-canonical tricarboxylic acid cycle underlies cellular identity.(accepted)

• Tumor-produced aging-associated oncometabolite, methylmalonic acid, promotes cancer-associated fibroblast activation to drive metastatic progression (under revision)
• Targeting oncoproteins with a positive selection assay for protein degraders.
• Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics
• Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia
• Age-induced accumulation of methylmalonic acid promotes tumor progression
• Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

• Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
• HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species

Undergraduate University: New York University

Publications:

• A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage

• Immune Cell-Stromal Circuitry in Lupus Photosensitivity

Undergraduate University: National Taiwan University

Publications:

• Immunity beyond cancer cells: perspective from tumor tissue

• Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis”

• Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis

Undergraduate University: Boston University

Publications:

• Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations

• Correlation of membrane protein conformational and functional dynamics

Undergraduate University: Northeastern University

Publications:

• Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer

Undergraduate Univeristy: Tsinghua University

Publications:

• Potent anti-tumor efficacy of palbociclib in treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine glioma

Undergraduate University: New York University

Publications:

• Superresolution visualization of distinct stalled and broken replication fork structures.

• “Building the Base: Why a More Diverse, Communication-Savvy Scientific Workforce is the Key to Addressing Future Catastrophes,” Science & Diplomacy.(Science & Diplomacy magazine)

Undergraduate University: CUNY York College

Undergraduate University: UCLA

Publications:

• ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs

Undergraduate University: Imperial College, London

Publications:

• Understanding the source of METTL3-independent m6A in mRNA.(manuscript in progress)
• The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells
• Structure mapping of dengue and Zika viruses reveals functional long-range interactions

Undergraduate University: Tufts University

Publications:

• Sequence and nuclease requirements for breakage and healing of a Structure-Forming (AT)n sequence within fragile site FRA16D 

• Identification of epsilon toxin-producing Clostridium perfringens strains in American retail food 

• Enrichment and Detection of Clostridium perfringens Toxinotypes in Retail Food Samples 

Undergraduate University: University of Washington, Seattle

Publications:

• Choroid plexus orchestrates leptomeningeal immunity (in preparation)
• Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites (in submission)
• The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites

• Characterization, isolation, and in vitro culture of leptomeningeal fibroblasts

• Leptomeningeal metastatic cells adopt two phenotypic states

• Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases

• Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters. Nature Scientific Report
• Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
• Cool night-time temperatures induce the expression of CONSTANS and FLOWERING LOCUS T to regulate flowering in Arabidopsis

Undergraduate University: Binghamton University 

Undergraduate University: UCLA

Publications:

• Germline competency of human embryonic stem cells depends on eomesodermin

• The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation

• Tankyrase inhibition sensitizes cells to CDK4 blockade

• GO: a functional reporter system to identify and enrich base editing activity

  
  

Undergraduate University: Harvard University

Undergraduate University: UCLA

Undergraduate University: University of Pennsylvania