BCMB Students: 2016 Entering Class

Undergraduate University: University of Pennsylvania

Thesis Lab:

Kristy Brown

Undergraduate University: Barnard College

Publications:

• Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells – a novel mechanism for the obesity-breast cancer link
• Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression
• Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice
• Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy
• Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
• Obesity-associated alterations in inflammation, epigenetics
• Metabolic obesity, adipose inflammation and elevated breast aromatase in women with normal body mass index
• Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF
• Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism

Thesis Lab:

Mary Baylies

Undergraduate University: University at Buffalo

Publication:

• Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation

Undergraduate University: The Hebrew University

Undergraduate University: Northeastern University

Publications:

• Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics

• In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

• Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Thesis Lab:

Lorenz Studer

Undergraduate University: Tsinghua University

Publication:

• Lipid deprivation induces a stable intermediate, naïve-to-primed state of pluripotency in human PSC

• High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain

Undergraduate University: University of Southern California

Publications:

• Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells

• Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease

Undergraduate University: University of Chicago

Publications:

• An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.

• Base editing goes into hyperdrive.

• A functional reporter system to identify and enrich base editing activity.

• Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
• Optimized base editors enable efficient editing in cells, organoids and mice.

Undergraduate University: Cornell University

Undergraduate University: Fordham University

• Role of Mitochondria in Ferroptosis

• Aiming at Cancer In Vivo: Ferroptosis-Inducer Delivered by Nanoparticles

• Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signaling

Undergraduate University: MIT University

Undergraduate University: Barnard College

Thesis Lab:

John Petrini

Undergraduate University: Universidad Complutense

Publication:

• Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

Undergraduate University: SASTRA University

Publications:

• Quantitative self-assembly prediction yields targeted nanomedicines.

Undergraduate University: Yeshiva University

Undergraduate University: Shanghai Jiao Tong University

Undergraduate University: Columbia University

Publications:

• Alpha-ketoglutarate links p53 to cell fate during tumor suppression.

• MAGI3-AKT3 fusion in breast cancer amended.

• RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs.

Undergraduate University: Universitat de Barcelona

Thesis Lab:

Frederic Geissman

Undergraduate University: Peking University

Publications:

• Tang Tao Transdermal Delivery of siRNA through Microneedle Array
• Local administration of siRNA through Microneedle: Optimization, Bio-distribution, Tumor Suppression and Toxicity