Graduate School of Medical Sciences

You are here

Lukas Dow

Assistant Professor

The Dow labĀ investigates the initiation, progression and response of colorectal cancer using in vivo animal model systems and ex vivo organotypic cultures. In collaboration with labs at Memorial Sloan Kettering Cancer Center and Cold Spring Harbor Laboratories, we have pioneered the development of next-generation technologies for animal studies, such as regulated miRNA-based shRNAs and CRISPR/Cas9 genome editing. We use these tools to generate tailored pre-clinical models based on genetic alterations frequently observed in human colorectal cancer (CRC) and investigate how genetic context and local environmental cues such as inflammation, influence the onset, progression and therapeutic response of CRC. By defining the critical drivers of cancer we aim to design strategies for more effective patient treatment.

Research Topics

Ready to start?
Apply now
Need more info?
Ask a question

Weill Cornell Medicine
Graduate School of Medical Sciences
1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-5981