Research
The Lewis lab research interests are focused on the development of radiopharmaceuticals and molecular imaging agents for targeted diagnosis and treatment of cancer. By combining small- and biomolecule-based targeting agents with positron-emitting or therapeutic radioisotopes, we can interrogate molecular profiles of cancer using noninvasive nuclear imaging or treat tumors specifically with radiopharmaceutical therapy. Our research program is a molecular-imaging-based program focused on the targeting of nonstandard nuclides, with an emphasis on developing these novel radiopharmaceuticals for clinical translation.
Figure 1
Current Projects:
- Precision Imaging with 89Zr-based PET Agents
- Targeting the acidic microenvironment with pH (Low) Insertion Peptide (pHLIP)
- Pretargeting cancer using bioorthogonal Diels-Alder click chemistry
- Treatment of cancer through Radiopharmaceutical Therapy (RPT)
Bio
Professor Jason S. Lewis earned a B.Sc. in Chemistry (1992) and a M.Sc. (1993) in Chemistry from the University of Essex and then in 1996 obtained a Ph.D. in Biochemistry from the University of Kent with Professor Philip J. Blower. His postdoctoral work was with Professors Carolyn J. Anderson and Michael J. Welch at the Washington University School of Medicine (WUSM). Subsequently he joined the WUSM faculty as an Assistant Professor of Radiology at the Mallinckrodt Institute of Radiology (2003-2008). Professor Lewis then joined MSK in 2008.
Distinctions:
- Fellow, World Molecular Imaging Society (2015)
- Michael J. Welch Award, Society of Nuclear Medicine and Molecular Imaging (2017)
- Paul C. Aebersold Award, Society of Nuclear Medicine and Molecular Imaging (2019)
- Fellow, Society of Nuclear Medicine and Molecular Imaging (2019)
- Fellow, Royal Society of Chemistry, United Kingdom (2019)
- American Chemical Society Bioconjugate Chemistry Lecture Award (2020)
- Fellow, American Association for the Advancement of Science (2020)
- Gold Medal for Lifetime Achievement, World Molecular Imaging Society (2021)
- Fellow, American Institute for Medical & Biological Engineering (2022)
- American Chemical Society - Glenn T. Seaborg Award for Nuclear Chemistry (2023)