Graduate School of Medical Sciences

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Cole Haynes

Adjunct Associate Professor

Mitochondrial dysfunction is associated with multiple pathologies including Parkinson’s disease, cancer, bacterial infection, and metabolic disorders as well as general aging. We investigate how cells adapt to survive the cause of mitochondrial dysfunction and ultimately recover mitochondrial activity.

We primarily focus on an intracellular signaling pathway known as the mitochondrial unfolded protein response (UPRmt).We’ve made significant progress towards understanding how cells monitor mitochondrial function and adapt transcription accordingly if the mitochondrial pool is compromised. Cells simply monitor mitochondrial protein import efficiency using the transcription factor ATFS-1 as a sentinel.

Research Topics

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Weill Cornell Medicine
Graduate School of Medical Sciences
1300 York Ave. Box 65 New York, NY 10065 Phone: (212) 746-6565 Fax: (212) 746-5981