Dr. Boskey studies the mechanism of biomineralization via analyses of the composition and structure of mineral and matrix in health and disease, the role of matrix constituents in mineralization, and the development of novel methods to assess mineral and matrix properties. Human conditions of particular interest are: dystrophic calcifications, growth plate abnormalities, osteoporosis, osteoarthritis, and osteogenesis imperfecta. Matrix constituents studied include: phospholipids, collagen, noncollagenous proteins, and proteoglycans. Techniques for analysis include: the gel diffusion system for the study of in vitro mineralization, FT-IR microspectroscopy and imaging and micro-computed tomography for the study of mineral and matrix properties, and wide angle x-ray diffraction. The ultimate goal of the studies is to improve bone quality by providing insight needed for new therapies and tissue engineered products.