Quarters I and II of this course provide a comprehensive overview of basic immunology beginning with the innate immune responses, followed by a study of the main aspects of acquired immunity. Specific interactions of target cells and T cells that are regulated by the MHC molecule and peptide antigens on the target cell and the antigen specific T cell receptor are studied. The generation and molecular structure of B and T cell antigen receptors, and signaling through immune receptors are covered in detail. Additionally, the development of antigen specific T and B cells, and specific roles for some cytokines/lymphokines are also explored. Quarters III and IV of the course cover in more depth T and B cell-mediated immunity and topics of clinical relevance, such as microbial immunity, allergy, autoimmunity, tumor immunology, congenital and acquired immunodeficiencies, transplantation immunology and immunotherapy. All the topics are studied though lectures and in-depth review of selected articles.