This course focuses on the underlying logic behind the design of scientific experiments. An emphasis is placed on understanding how hypotheses are generated and how variables, assays, rationales and model building are utilized in experimental design. Each class focuses on a recent paper in scientific literature and uses the paper as a starting point for discussion. Students are expected to propose and justify novel experiments based on the paper and discussion. Students are encouraged to use "Protocols in Molecular Biology," as well as other resources to become familiar with the methodology, advantages and limitations of the experimental approaches used in the papers. It is expected that students will have to read background papers for each of the papers discussed in class.