Recent public debates about conflicts of interests, exploitation of human subjects and scientific fraud have brought to the forefront the importance of ethical reflection in the context of biomedical investigations. This course examines various ethical aspects that arise when conducting biomedical research. In order to evaluate such ethical concerns this course will review and critically analyze the philosophical underpinnings of current guidelines and regulations for the responsible conduct of research. Different aspects of doing research where moral decision-making is necessary will be considered, as well as discussion of investigators’ responsibilities as members of the scientific community and gatekeepers of public trust in science.